![]() CCK8 assay, wound healing method and immunostaining were used to observe the effect of SABP on fibroblasts proliferation, migration and transformation into myofibroblasts. Adventitial fibroblasts were isolated and cultured from the adventitia of thoracic aorta in SHR and WKY rats. The effects of SABP on oxidative stress, inflammation, and vascular remodeling were investigated by transmission electron microscopy, histochemical staining, and Western blot. Methods: SABP or perindopril (positive control) were administered intraperitoneally to SHRs, and systolic blood pressure was measured using a tail-cuff approach. Additionally, the response of adventitial fibroblasts in SHRs to SABP treatment was also studied, including their proliferation, differentiation, and migration. Objective: This study aimed to determine the effects of SABP on vascular inflammation, oxidative stress, and vascular remodeling in spontaneously hypertensive rats (SHRs). However, the underlying mechanisms remain unknown. Previous studies have shown that SABP, a combination of aqueous active metabolites of Salvia Miltiorrhiza Bunge DSS, Sal-A, Sal-B and PAL, has a significant antihypertensive effect. Despite the availability of antihypertensive drugs, alternative treatments are needed due to the adverse events associated with their use. 3Medical College, Hebei University of Engineering, Handan Economoc and Technological Development Zone, Handan, Hebei, Chinaīackground: Hypertension is a major risk factor for cardiovascular diseases and the leading cause of mortality worldwide.2College of Integrated Chinese and western medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. ![]() 1Hebei Provincial Engineering Laboratory of Plant Bioreactor Preparation Technology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China.Ruoyu Wu 1,2 †, Yongjie Zhou 1,2 †, Hongjun Xu 1,2 †, Wei Zhao 1,2,3, Luyang Zhou 1,2, Yilin Zhao 1,2, Qingzhuo Cui 1,2, Junda Ning 1,2, Hongxu Chen 1,2* and Shengjun An 1,2*
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